الفهرس 
HypothyroidismOnly 14 pages are availabe for public view
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Abstract
Summary and conclusion
The thyroid gland is one of the most important endocrine glands of the body. In fact, this little butterfly-shaped part of the endocrine system is essential to everyday health.
Thyroid disease is a global health problem that can substantially impact well-being, particularly in pregnancy and childhood. Hypothyroidism is one of the most common diseases of endocrine system.
Regarding hypothyroidism, the risk increases with age, the incidence is 4 times greater in women than in men, Iodine deficiency and autoimmune disease (Hashimoto thyroiditis) account for the vast majority of cases of primary hypothyroidism and Subclinical hypothyroidism is more prevalent than overt disease.
Various changes in the hemostatic profile have been described in patients with excess and deficiency of thyroid hormones. The cardiovascular system is an important target of thyroid hormones actions and is sensitive to slight variations in circulating thyroid hormones levels.
Coronary artery disease (CAD) is the leading cause of death in many developed countries.
Platelets play a crucial role in the pathophysiology of atherosclerotic diseases that are related to thrombosis, inflammation, and angiogenesis. Large platelets are more active hemostatically and enzymatically, and they contain more prothrombotic molecules.
Mean platelet volume (MPV) and platelet distribution width (PDW) are platelet parameters which asses platelet size of circulating platelets and