الفهرس 
AcknowledgementOnly 14 pages are availabe for public view
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Abstract
The aim of this study was to evaluate the antifungal effect of aqueous extract of siwak solution on candida albicans. Also to evaluate the color change and flexure strength of acrylic denture base material after immersion in aqueous extract of siwak solution in comparison to distilled water as a negative control or 0.5% sodium hypochlorite as a positive control. One commercially available heat cured acrylic resin denture base material was used in this study: (Vertex rapid simplified heat cured acrylic resin denture base material).
In the present study, a total number of 162 specimens were prepared. The specimens were randomly assigned into three groups (I, II, III) according to the type of the immersion solution. group I represent the aqueous extract of siwak, group II represent the distilled water, while group III represents 0.5% sodium hypochlorite.
Regarding the antifungal evaluation, it was done using two techniques; the agar diffusion method and the agar dilution method. Twenty seven specimens (9 specimens/group) were included for each test in the antifungal evaluation. Measurement was done once after 24 hours of the immersion protocol.
Twenty seven specimens (9 specimens/group) were included for color change assessment; measurements were done using the same specimens before immersion, after 24 hours and after three months of the immersion protocol using Cary 5000 Spectrophotometer provided from Agilent Technologies (USA).
For Flexure strength testing, total sample size of 81 specimens were included (9 specimens/group). Measurements were done using different specimens before immersion, after 24 hours and after three months of the immersion protocol using a universal testing machine with a load cell of 5 kN, then the samples were loaded until fracture at a crosshead speed of 1 mm/min.
All specimens were prepared according to manufacturer’s instructions using teflon molds with different dimensions according to each test specifications: The antifungal tests specimens were prepared with dimensions of (4mm thickness×4mm diameter), the color change test specimens were prepared with dimensions (10mm thickness×10mm diameter) and the flexure strength test specimens were prepared with dimensions (65mm×10mm×2.5mm).
Regarding the agar diffusion method, there was statistically significant difference found between the antifungal activities of the three groups. The highest mean antifungal activity was recorded for specimens immersed in aqueous extract of siwak solution (group I), followed by specimens immersed in 0.5 % sodium hypochlorite solution (group III). While the least mean value was recorded for specimens immersed in distilled water (group II).