الفهرس 
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Abstract
Head and neck squamous cell carcinoma (HNSCC) has an estimated incidence of approximately 65,000 annual cases. MRI-guided radiotherapy planning (MRIgRT) may be superior to CT-guided planning in some instances owing to its improved soft-tissue contrast. No robust quality assessment of commercially available MR-CT registration algorithms is yet available
The major advantage of proton therapy treatment over standard radiation therapy, however, is that protons slowly deposit their energy as they travel towards the tumor and then due to a unique physical characteristic called the Bragg Peak, deposit the majority of the radiation dose directly in the tumor and travel no further through the body.
We aimed To Compare Intensity Modulated Radiotherapy (IMRT) to Intensity Modulated Proton Therapy (IMPT) regarding the effect on the different normal tissue tolerance. As well as to Assess the quality of MR-CT co-registration using commercially available image registration software in HNC cancer patients receiving definitive RT and explore whether SI kinetics obtained from serial MRI in non-target swallowing muscles could serve as a potential imaging biomarker of radiation-associated dysphagia.
Forty-six patients were included in the study, all with AJCC stage III/IV HPV+ OPC treated at MD Anderson Cancer Center between February 2013 and November 2015. They were classified into two groups to compare IMPT to IMRT. Different VOIs were contoured for assessing the MRI SI changes during RT and to compare the different registration commercially available.