الفهرس 
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Abstract
Pyrroles, pyrazoles, thiozoles and azoles represent molecular frame work
that serve as platform for developing pharmaceutical agents for various
application. We have attempted a straight forward synthesis of new heterocyclic
progesterone derivatives. The structures of all synthesized compounds were confirmed by spectral and analytical data which were in agreement with the assigned structures. The synthesized compounds were tested as anticancer agents and proved their activities .
Treatment of progesterone (1) with 2-cyanoacetohydrazine(2) in acetic acid
(2-Cyano –N-N ((E)-1-((4AS,5S)-4a-methyldecahydro-1 H–cyclobuta[e]inden-5-yl ) ethylidene ) acetohydrazide(3) (scheme 1)
Scheme 1
Reaction of compound 3with mixture of malononitrile ( 4a) and sulfurorethyl
cyano acetate (4b) in presence of triethylamine and DMF as solvent formed(6a)and
(6b)bycyclization3,5diamino-4-cyano-methyl bicyclo[3.2]heptan-2-yl)ethylidene )
thiophene -2-carbohydrazide(6a)and 3,5 diamino-4-cyano-methyl bicyclo[3,2]
heptan-2-yl)hydrazine-1-carbonyl)thiophene-3-carboxylate(6b) respectively
(Scheme 2) .
Scheme 2
The reactivity of compounds 3 towards the reaction with isothiocyante was studied
in the aim of forming newthiazolesteroids.Thus,compound3 reacted with
equimolar amount of phenylisothiocyanate, sulfur and triethylamine in presence of
dioxane as solvent and the mixture path to intermediate point then convert by
cyclization to compound 7