الفهرس 
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Abstract
Vitiligo is an acquired skin depigmentation disorder affecting 0.5 - 1% of the world population. The disease may affect individuals of both sexes. It occurs when melanocytes die or unable to function and mostly characterized by loss of melanocytes .Despite much research, the etiology of vitiligo and melanocyte death is not clear. It is related to both genetic and non-genetic factors, but there are many theories concerning the cause such as the autoimmune, autocytotoxic and neural hypothesis.
High-mobility group box 1 (HMGB1) is a nonhistone DNA-binding protein active in the bending of DNA and in transcriptional regulation that participates in a number of physiological and pathological processes. HMGB1 has been linked to various autoimmune conditions, including systemic lupus erythematosus (SLE), cutaneous lupus erythematosus and rheumatoid arthritis.
The aim of this study was to measure blood level of HMGB1 in patients with vitiligo to determine its possible role in the pathogenesis and progress of vitiligo.
This study was carried out at Dermatology and Medical Biochemistry Departments, Menoufia Faculty of Medicine. It included 40 patients with vitiligo during the period from February 2019 to June 2019. In addition to 40 age and gender matched healthy individuals, served as control group.
All studied individuals were subjected to complete history taking as personal history, present history, family history, history of drug intake, history of other dermatological autoimmune diseases, history of systemic diseases and thorough general and dermatological examination. VASI scores was assessed. plasma levels of HMGB1 was estimated after taking an informed consent.
The results of this study revealed the following:
The mean age of vitiligo group was 26.15±17.84 years while in the control group; it was 28.23±17.75 years.
The male percentage was 42.5% in patients’ group and it was 57.5% in the control group.
- The female percentage was 57.5% in patients’ group and it was 42.5% in the control group.
- The mean duration of vitiligo lesions was 6.93±2.93 y.
- VASI score ranged from 0.750-38 with mean of 5.17±8.45.
- Positive family history of vitiligo was reported in 3 patients (7.5%).
- Vitiligo Vulgaris was the main clinical pattern of patients` group.
- There was statistically significant increase of plasma HMGB1 level in vitiligo patients than in control group.
- There was non significant correlation between HMGB1 and clinical parameters such as age, sex, disease onset, duration of recent aggravation or percentage of vitiligo involvement.