الفهرس 
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Abstract
Systemic lupus erythematosus (SLE) is a chronic autoimmune disease that has variable manifestations. More than 90% of cases of SLE occur in women, frequently starting at childbearing age. It can affect almost any organ system; thus, its presentation and course are highly variable, ranging from indolent to fulminate. The disease course is characterized by exacerbations and remissions, with the development of new organ manifestations or progression of existing manifestations (Bartels et al., 2016).
Aim of this study was to assess pattern of Systemic Lupus Erythematosus at Sohag Government regarding disease presentation, disease course, response to treatment and outcomes of the disease.
Mean age of our study group was 36.19 years with SD 11.8 years, and wide range from 11 to 65 years, our study group included 14% males and 86% females. 62% of our study group were from rural areas and 38% were from urban areas. Also in study of Faezi et al. (2014) female patients constituted the majority of their studied SLE patients which was similar to other studies of large series in SLE Garcia et al. (2005), Stefanidou et al. (2011), Mongkoltanatus et al. (2007).
Regarding SLE manifestations, 16% of our cases had current fever, 24% had arthritis, 74% of our cases had current acute cutaneous manifestations, 4% had subacute cutaneous, only 2% had chronic cutaneous, 35% had oral or nasal ulcer, 37% had alopecia, , 15% had serositis. 35% had various pulmonary manifestations as cough, dyspnea, chest pain and ILD. We found that 27% of our cases had cardiovascular manifestations as dyspnea, orthopnea, cyanosis and valvular heart affection, 52% had current LN and only 9% had neurologic manifestations. Vasculitis was found current in only 7.5% of cases, on the other hand no any cases found had CVA or myositis or visual manifestations.
ANA pattern was negative in 4% of our cases, positive homogenous in 29.5% of cases, 0.5% had homogenous&speckled pattern, positive anticytoplasmic ribosomal antibody in 1% of our cases, and 65% had speckled pattern. We found that most of our cases had ANA titre 1\80 (23%) followed by 1\160 (20%), then 1\320 (11.5%) then 1\40 (10.5%). Anti DsDna found positive in 24% of our cases followed by anti nucleosome (16.5%), then anti Ro52 (11.5%), anti Ro 60 was positive in 7.5%, anti Pcna (5.5%), and anti histone positive in only 4% of our cases, on the other hand 21% of our cases were negative ANA.
Conclusion
In this study, majority of patients presented with combination of fever, rash, alopecia, oral ulcers and arthritis. Almost 31% of patients had renal manifestations. Delay in identifying such findings can lead to fatal morbidity and mortality. We conclude the characteristic pattern of SLE in Sohag to facilitate the diagnosis and specific treatement before the appearance of complications.