الفهرس 
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Abstract
This present study aimed to detect the expression of Nuclear factor Kappa B in psoriatic skin of diseased patients as compared to normal control persons to investigate the possible role ofNuclear factor Kappa B in the pathogenesis of thisdisease.
It was a case-control study conducted in dermatology outpatient clinic at Beni-Suef University hospital during the period from (10 November 2018) to (1 April 2019). The study included 60 individuals; 30 as psoriasis cases selected randomly from the dermatology outpatient clinic according to the inclusion and exclusion criteria, and 30 matched controls.
All the sixty individuals included in the study was subjected to a written informed consent for participation in the study, detailed history taking, clinical assessment to determine type, extent and sites of Psoriasis. Then all participants underwent four mm punch skin biopsy from patients (psoriasis lesion) & control and, it was kept in lysis solution for the stability of the studied parameters and kept frozen at -80 Celsius till analysis of NFKB by real time -PCR.
The collected data were coded then entered and analyzed taking three months using the SPSS version 25.
The study revealed that the average patient age was 41.43 ±12.9(SD) years and gender distribution as40%of patients were females and 60% were males with no statistically significant difference between cases and control groups regarding age and sex. The analysis of Nuclear factor Kappa B values in the punch skin biopsy from our studied population (patients with psoriasis lesion & control skin) reveled that; the level of Nuclear factor Kappa B values were significantly higher among patients with psoriasis as compared with normal control where the level was (4.61 ±2.4 vs. 1.03 ±0.12) in psoriatic patients and controls respectively with a significant p-value <0.001.