الفهرس 
REVIEW OF LITERATUREOnly 14 pages are availabe for public view
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Abstract
Psoriasis is a common, chronic, relapsing disorder that has been reported in 2% of worldwide populations.
Hyperproliferation and altered differentiation of keratinocytes is the main pathology of psoriasis. BCAP31 is an integral membrane protein of endoplasmic reticulum. Cleaved BCAP31 induces proliferation while full length protein induces apoptosis.
The current study aimed at evaluation of the possible role of BCAP31 in the pathogenesis of psoriasis through its immunohistochemical localization in involved psoriatic skin compared to normal skin in addition of correlating BCAP31 expression with the clinical and pathological parameters of psoriasis.
The study was carried out on thirty patients presented with psoriasis and ten apparently normal individuals. They were selected from Outpatient Clinics of Dermatology and Plastic Surgery Departments, Faculty of Medicine, Menoufia University. All participants were subjected to complete history taking and through clinical examination. PASI score was used to assess psoriasis severity. A skin punch biopsies was taken from every participant, the biopsies were processed in Pathology Department, Faculty of Medicine, Menoufia University. from each block, 2 sections were cut , one was stained by haematoxylin and eosin for evaluation of psoriasis histopathological changes such as acanthosis, parakeratosis, angiogenesis and inflammation. Other section was cut on poly L lysine coated slides for immunostaining procedure.
BCAP31 was upregulated in involved skin of psoriatic lesions (50% in epidermis and 86.7% in dermis) and was absent in controls either epidermis or dermis with a highly significant difference (p=0.006, p<0.001).
BCAP 31 was expressed in 15 cases (50%) out of 30 cases in the epidermis that was focal in 9 cases (30%) and diffuse in 6 cases (20%). Intensity of BCAP31 was mild in 10 cases (33.3%) moderate in 2 cases (6.7%) and strong in 3 cases (10%).
There was a significant association between the intensity of epidermal BCAP31 expression and degree of parakeratosis (p=0.025), since strong intensity was associated with marked parakratosis.
There was significant association between epidermal and dermal expression of BCAP31 (coparallel expression) (P<0.001).