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Abstract Aim of the work: The main goals of our studies are: Construction of a novel heterocyclic compounds containing nitrogen and sulfur. Elucidate the structure of the synthesized compounds using spectroscopic tools such as IR, 1H NMR, 13C NMR spectroscopy, mass spectrometry and elemental analyses. Confirmation of the structures using X-ray crystallography analyses. Detection of the reactive sites in donor compounds, the mode of cyclization, and rationale for the formation of the products. Overviewing the general applications of the synthesized heterocyclic nucleus. Introduction:- Discuss the structure features of thiazine derivatives, their biological activity, methods of preparation as well as the chemical reactions. In The results and discussion: Thiosemicarbazide derivatives have been used as nitrogen and sulfur containing compounds (electron-donors) to react with –deficient compounds (electron acceptors). Part 1: The reaction between thiosemicarbazides with 2,3-diphenylcyclopropenone furnished the thiazinane derivatives as well as the acrylohydrazide. Part 2: While, the reaction between thiosemi-carbazides with 2,3,5,6-tetrachlorobenzoquinone using Eshenmoser-contracting to give the diazinyltriazole derivatives. Part 3: On the other hand, thiosemiicarbazides have been reacted with phenacylbromide derivatives and thiazole derivatives have been obtained. Part 4: On reacting, thiosemicarbazides with indandionemethylene dicarbonitrile (CNIND), fused heterocyclic [3.3.3.]propellane s have been obtained. Part 5: Lastly, the reaction between thiosemi-carbazides with dialkyl acetylenedicarboxylate gave the thiazolidinone derivaties. The chemical structures of the obtained compounds have been determined using spectroscopic analyses (IR, HNMR, and CNMR) and mass sspectometry. The X-ray crystallography have been used to confirm the structures. |