الفهرس 
Anatomy of the Brain
Neurocognitive Alterations in Type 1 Diabetes MellitusOnly 14 pages are availabe for public view
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Abstract
Summary and Conclusion The concentration of various metabolites can be quantified noninvasively in the human brain using proton magnetic resonance spectroscopy (1H-MRS). Long term impairment of cognitive function can occur in patients with T1DM, especially those with poor glycemic control. MRS of the brain in children with T1DM can be used to detect the cerebral metabolic changes that occur with DM. This neuro-chemical profile can provide new information regarding the neurocognitive alterations that can occur in these patients. In this study MR spectroscopic analysis was performed on 25 children diagnosed with T1DM and 25age-matched volunteer healthy subjects. Voxels were placed in three regions of interest; the left posterior parietal white matter, left basal ganglia and the pons. Type 1 diabetic subjects had lower NAA/Cr ratio in the white matter and pons than control subjects. Longer duration of DM and increased number of DKA episodes predicted lower NAA/Cr ratio. The decrease in NAA indicates reduced neuronal density or neuronal dysfunction as a consequence of long term poorly controlled T1DM. The study also revealed slightly higher Cho /Cr ratios in the basal ganglia and pons in diabetic patients. The explanation for the increase in Cho may be demyelination/gliosis or increased membrane turnover. The study revealed high level of mI/Cr in the basal ganglia in diabetic Patients. The