الفهرس 
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Abstract
Background: Emerging evidence suggests that subjects with NAFLD have an increased risk of chronic kidney disease (CKD), defined by a decline in the estimated glomerular filtration rate (EGFR) and/or microalbuminuria and/or overt proteinuria. This may be attributed to similar traditional risk factors for CKD including hypertension, obesity, dyslipidemia and insulin resistance. Molecular mechanisms that represent crosstalk between liver and kidney include altered renin-angiotensin system (RAS) activation, impaired antioxidant defense, and damaged lipogenesis. The aim of the work:. This study is carried out to determine whether children with overweight/obesity and NAFLD show renal functional alterations, as assessed by EGFR and urinary albumin excretion, compared to children with overweight/obesity but without NAFLD as well as to healthy normal-weight control Type of study: retrospective cohort study Materials and Methods This retrospective cohort study included 50 patients (16 female and 34 male) it was carried in the Pediatric Endocrinology and Diabetes Outpatient Clinic in Mansoura University Children’s Hospital (MUCH) from March 2017 to March 2018. Twenty five age and sex matched healthy controls were included in the study Signed informed consents were obtained from the parents of all children to be enrolled in the study.Results: In our study, there was no statistically significant difference between obese FL, obese NFL group and control group regarding to Serum creatinine (Scr), there was no statistically significant difference between obese FL, obese NFL group and control group regarding to Glomerular Filtration Rate (GFR). ; inspite of there was significant difference between the three studied groups with the highest value to NFL ,all microalbumin levels in the three studied groups were within the norml range.Conclusion: Based on the results of our study, it could be included that:Obesity in children was associated with higher risk for abnormal elevation of lipid profile, liver enzyme among the cases in the study.Obesity was not associated with affection of the serum creatinine or GFR and microalbumin in urine.The association between NAFLD and CKD; not found in our study , may be due to short duration of obesity , the number of cases may be not enough, the follow up may be more longer time.Recommendations: Choose cases with longer duration of obesity.follow up of obese children with or without NAFLD for longer duration.