الفهرس 
INTRODUCTIONOnly 14 pages are availabe for public view
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Abstract
The hematological malignancies are a complex group of neoplastic diseases, linked by their origin in bone marrow derived cells. The growing understanding of how hematological malignancies arise through disruption of the normal cellular processes in the bone marrow and immune system by a variety of molecular and cytogenetic abnormalities is challenging traditional approaches to disease classification.
Pulmonary complications are widely reported in such cases with a variety of symptoms such as dyspnea (50%), cough (34.8%), fever (34.8%), and chest pain (10.9%). Some patients presented with a combination of symptoms at time of examination. Complications could be generally classified into two groups as neoplastic and non-neoplastic with pulmonary infection making up the majority of the latter.
The aim of the work was to study role of MDCT in detection of pulmonary complications in hematological malignancies.
This prospective study was carried out on 46 patients who referred to Radiology department of Alexandria University Main Hospitals.
All patients in our study were examined by MDCT with contrast after careful history taking and basic laboratory investigations in hematology department. They were 25 males (54.3%) and 21 females (45.7%) with male to female ratio of 1.2: 1. Their ages ranged between 14 and 79 years. We noticed that the most affected age group was those between 50 and 60 years.
We were able to detect wide spectrum of radiological findings regarding pulmonary complications. They were pulmonary nodules in 65.2%, ground glass opacities in 43.5%, enlarged lymph nodes in 34,8%, atelectatic bands in 30.4%, pleural effusion in 28.3% consolidative patches in 26.1%, bronchiectatic changes in 19.6%. Some patients presented with a combination of radiological manifestations in MDCT results.
Multi Detector Computed Tomography is currently the imaging modality of choice in diagnosis of pulmonary complications of hematological malignancies being superior to chest radiography in demonstrating the presence and extent of lung abnormalities.
MDCT is the most sensitive mean to detect lung pathology and it shows significant superiority over plain chest radiography in obtaining specific diagnosis in various forms of pulmonary complications mentioned above.
Also, it offers the possibility of a non-invasive and accurate imaging of pulmonary abnormalities in the evaluation, diagnosis and follow up of the management of the patients with pulmonary complications in patients with hematological malignancies.