الفهرس 
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Abstract
Summary
Systemic lupus erythematosus (SLE) is a systemic autoimmune disease with high heterogeneity that predominantly affects women, especially those of reproductive age (Mok et al .,2018)
SLE is characterised by autoantibody formation against nuclear antigens with resultant inflammation in organs such as the kidney, skin and joints. SLE is notorious for its markedly heterogeneous clinical phenotype, with a multifactorial aetiology that depends on genetic, epigenetic and environmental influences (Tsokos et al ., 2011).
In SLE, B2M concentration rises during inflammatory conditions. Positive correlations have been reported between B2M levels and SLE disease activity index (SLEDAI) (Umare et al ., 2017)
The aim of this study was To assess serum level of B2microglobulin (B2M) in systemic lupus erythematosus (SLE) patients and find its Correlation with disease activity and damage.
This study was conducted on 50 clinically diagnosed SLE patients And 50 healthy controls.
The patients were diagnosed according to Systemic Lupus International Collaborating Clinics ( SLICC) classification criteria for SLE (petri et al.,2012).
All were subjected to full clinical history and examination, complete blood count, ESR, B2M , ANA , Ds DNA , C3, C4,liver enzymes serum creatinine ,uric acid , Complete urine analysis ,24 hours urinary protein, serum B2M by ELISA technique.
Renal Biopsy was done and classified according to the to the classification of lupus nephritis by the International Society of Nephrology/Renal Pathology Society (ISN/RPS) (Weening et al.,2004).
This study demonstrated the following:
serum B2M level are higher in SLE patients than healthy subjects.
serum levels B2M were significantly correlated with the SLEDAI scores , HDL and , neurologic disease .
Conclusion
The study concluded that B2M concentrations were significantly elevated in SLE patients and correlated with the SLEDAI score. Indicating their direct involvement in inflammatory conditions associated with disease.