الفهرس 
Acute Lymphoblastic LeukemiaOnly 14 pages are availabe for public view
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Abstract
Chemokines are a superfamily of chemoattracting, cytokine-like proteins that bind to and activate a family of chemokine receptors. Over 50 chemokines have been identified and they are divided into four families (CXC, CX3C, CC, and C) on the basis of the positions of four conserved cysteine residues.Chemokine receptors are seven-transmemberane receptors coupled to G proteins, all with their N terminus outside the cell surface, three extracellular and three intracellular l00ps as well as a C terminus in the cytoplasm. One of the intracellular l00ps of the chemokine receptors couples with heterotrimeric G proteins and that mediate ligand binding to the receptor which initiates a cascade of signal transduction events.CXCR7 expression has been found in T lymphocytes and during CXCL12-mediated chemotaxis. CXCR7 expression is tightly regulated in B cell development and differentiation. The expression of CXCR7 correlates with the ability of B cells to differentiate into plasma cells upon activation and suggesting that CXCR7 is a marker for memory B cells, which are competent to become antibody secreting cells.This is a case control study conducted on 50 children with acute lymphoblastic leukemia recruited from Pediatric oncology Unit of Tanta University Hospital and a group of 30 healthy children with matched age and sex serving as controls. The aim of the current study was to investigated the CXCR7 expression in ALL.