الفهرس 
EPIDEMIOLOGYOnly 14 pages are availabe for public view
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Abstract
Triple negative breast cancer (TNBC) which lack expression of ER, PR and HER2 is relatively aggressive tumor biology. Patients with TNBC have significantly worse prognosis compared to other subtypes of breast carcinoma due to lack of well defined targeted molecular therapy and endocrinal therapy. This is a clinico-pathological and immunohistochemical retrospective study included 100 patients with non metastatic TNBC treated at Clinical Oncology and Nuclear Medicine Department Tanta University Hospital throughout the period from January 2011 to December 2017. The aim of this work is to determine the prevalence of AR expression in TNBC, correlate AR status with clinico-pathologic finding and correlate AR expression with DFS and OS to assess its prognostic significance. Immunohistochemistry was performed on Formalin Fixed Paraffin Embedded tissue sections from tumor specimens using standard procedure to evaluate AR. Androgen receptor expression was assessed on the basis of nuclear staining, more than 10% of tumor cells nuclei stained were considered positive. The age of patients ranged from 28 to 70 years and the median age was 45 years. Androgen receptor expression was demonstrated in 33% of patients. In our study, TNBC patients had relatively large tumors at presentation (more than 2 cm in 72% of patients), post menopausal (58%), predominant type of tumor was IDC (80%), poorly differentiated (47%) and high ki-67 > 16% (63%). Almost more than half of patients (85%) had positive axillary lymph nodes and thirty three patients (33%) were positive for AR expression at presentation. Positive AR were most significantly related to post menopausal status (p=0.012), small tumor size (p<0.001), grade II (p<0.001), lower KI67 (p<0.001) and -ve lympho vascular invasion (p<0.001). In our study as a whole, The two-year OS was 72% while the 5-year OS was 39%. As regards DFS in the whole study group, the 2-year DFS was 46% while the 5-year DFS was 29%. In the present study, univariate analysis retained the significant prognostic value of AR state, tumor size, lymph node state,tumor grade, KI 67 and lympho vascular invasion which had significant impact on DFS as well as on OS.