الفهرس 
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Abstract
The present thesis involves the quantitation of some selected cardiovascular drugs. The developed methods were either spectrophotometric methods or RP-HPLC methods. The developed methods were optimized and validated. Part I: General introduction This part represents a general introduction about cardiovascular diseases and cardiovascular drugs including their classification and mechanisms of action. Part II: Development and validation of new analytical methods for simultaneous determination of aspirin and omeprazole This part consists of four chapters: Chapter 1: Review of literature This chapter includes an introduction about the chemical and physicochemical properties of aspirin and omeprazole. Also it includes a review of literature about the analytical methods recently reported for estimation of both drugs in single dosage form and in combinations. Chapter 2: First derivative (1D) spectrophotometric method for simultaneous determination of aspirin and omeprazole This chapter presents an introduction about the first derivative spectrophotometric method and its advantages. This chapter represents the development and validation of first derivative spectrophotometric method for simultaneous determination of aspirin and omeprazole in their binary mixtures. In this method, analytical signals at 281.3 and 297 nm were selected for the determination of ASP and OMP, respectively using 0.1N NaOH as solvent. The developed methods were validated and successfully applied to the simultaneous determination of ASP and OMP in their laboratory prepared tablets containing all possible excipients present in tablet dosage form.