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Abstract Skin grafting has evolved in the past centuries to encompass numerous well-established reconstruction techniques that are uniquely able to restore structure, function, and cosmoses to a variety of surgical wounds. Autologous split skin grafting was the gold standard in treating patients with massive burns for decades, split skin grafting may be limited by donor site availability. To overcome this clinical barrier, a number of techniques have been developed to allow for skin graft expansion including mesh grafting or micrografting. Large post burn raw areas in children is very challenging so a clinical prospective study was introduced comparing the use of mini autogenous skin grafts covered by skin homografts versus autogenous skin grafts for covering post burn wounds in children so the patient can continue on his/her normal life early with deformities. This study was done on 20 children patients with post burn raw areas who were treated as inpatients at the Burn Unit in Assuit University Hospital from September 2017 to September 2019. The study included two groups of children patients with post burn raw areas to compare the outcome of their treatment: group I: it is formed of 10 children (8 males and 2 females) with post burn raw areas who were treated by covering the wounds with mini autogenous skin grafts and skin homo grafts. group II: it is formed of 10 children (7 males and 3 females) with post burn raw areas who were treated with the conventional autogenous skin grafts. The results showed that there were statistical significance between group I and group II in Intra operative donor site percentage to raw area percentageIntra operative time of operation to raw area percentage.Intra operative donor site bleeding to raw area percentage. Take of the graft. Graft complications. Graft pigmentation. Conclusion It provides the covering for wide raw areas in presence of shortage of donor sites. The use of MEBO in post-operative dressings improves greatly the result of this technique by rapid epithelization of any residual raw areas with less scarring. |