الفهرس 
Clinical overview of thalassemia syndromesOnly 14 pages are availabe for public view
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Abstract
Hemoglobin hereditary disorders are the most common human monogenic diseases. It has been estimated that approximately 7% of the world population are carriers, and about 300000–500000 babies with severe forms of these conditions are born each year. Because these conditions occur at their highest frequency across the tropical regions of the world, they pose a particular problem for the developing countries. The high frequency of beta-thalassemia carriers with the increase in newborn cases is a pressing reason for developing β-thalassemia prevention programs in Egypt.
The best approach to the control of the thalassemia is based on population screening and genetic counseling. Counseling of thalassemia carriers is usually limited to explaining the carrier state’s effects on the likelihood of having a severely affected infant, which is 25% if both parents were carriers. Quantitative HbA2 determination is the most valuable test for β‐thalassemia carrier detection; however, it could be normal in some atypical mutation of B gene and in heterozygote α thalassemia. The aim of this work was to detect the frequency of thalassemia trait among the high school students in El-Shohadaa, Menoufia Governorate, and to update the carrier rate data in Menoufia Governorate that could be used for prevention program of β thalassemia. The present study was carried out on 346 high school students in El-Shohadaa city, Menoufia Governorate, Egypt.