الفهرس 
Acknowledgments
Non Hodgkin lymphomaOnly 14 pages are availabe for public view
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Abstract
According to the stage of the disease and Ann Arbor classification; there were 4 patients at stage I, 6 at stage II, 6 at stage III and 16 patients were at stage IV. There were 16 patients that bone marrow infiltrated and 16 others were not infiltrated.
According to behavior; we studied 11 low grade, 16 aggressive and 5 patients with very aggressive manner in behaviour. However, according to IPI; there were 9 patients with low risk IPI, 8 with low intermediate risk, 5 with high intermediate risk and 10 patients with high risk IPI.
Thirty subjects, apparently healthy 18 males and 12 females aged 3 to 81 years were included as a control group.
Each patient had certain investigations; CBC, serum LDH, bone marrow aspiration and biopsy and miR-155 by Real time PCR in both peripheral and bone marrow samples.
Our study results revealed that miR-155 expression levels were directly proportional to age, advanced clinical stage (according to Ann Arbor classification), high IPI score and infiltrated bone marrow. While, there was no correlation between miR-155 expression and sex or behavior of the disease.
So that; we could conclude that miR-155 could be considered as a novel predictive important biomarker of B-NHLs and a good indicator of clinical state or progression of the disease.