الفهرس 
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Abstract
This Thesis Comprises Five Chapters. The First One Is A Literature Review Containing A Brief Survey On The Pathological View Of Inflammation And Different Drugs Used For Treatment Of Inflammation. It Also Gives Different Methods Used For Synthesis Of New Nsaids Containing Pyrazole, Triazole Or Tetrazole Ring And Their Anti-Inflammatory Activities.
The Second Chapter Deals With The Aim Of This Work And Schemes That Have Been Carried Out To Obtain The New Target Pyrazole, Triazole And Tetrazole Compounds.
The Third Chapter Explains The Theoretical Discussion Of The Experimental Work For The Preparation Of Starting Materials (Ia And Ib) The Intermediates (Iiia-D, Iva-D, Viia-L, Xia,B, Xiia-J, XIV, XV, XVII, XVIII And XIX) In Addition To The Synthesis Of Novel Target Compounds (Vb-D, Via-H, Ixa-L, Xiiia-J, XVI, XX, XXI, XXII And XXIII).
Condensation Of Different Acetophenones Iia-D With 4-Hydrazineyl Benzenesulfonamide Hydrochloride (Ia) Gave Hydrazones Iiia-D. Applying Vilsmier-Hacck Reaction Conditions To Iiia-D Followed By Hydrolysis With Methanolic Sodium Hydroxide Gave Pyrazole Aldehydes Va-D.
Condensation Of Pyrazoles Va-D With Either 4-Hydrazineyl Benzenesulfonamide Hydrochloride (Ia) Or 4-Methanesulfonylphenylhydrazine Hydrochloride (Ib) Afforded Target Compounds Via-H.
Also, The Reaction Of Acetophenones Iia-C, Iie With Different Aldehydes Via Clasien–Schmidt Conditions Gave Chalcones Viia-L, Which Upon Cyclization With 4-Hydrazineylbenzenesulfonamide Hydrochloride (Ia) Either In Boiling Ethanol Or Glacial Acetic Acid Produced Pyrazoles Ixa-L.
In Addition, The Reaction Of Benzamidoacetic Acids Xia-B With Different Aromatic Aldehydes In Acetic Anhydride Containing Catalytic Amount Of Sodium Acetate Afforded Oxazolones Xiia-J, That Were Further Reacted With Sodium Azide In Glacial Acetic Acid To Give Tetrazoles Xiiia-J.
Furthermore, The Reaction Of 4-Azidobenzenesulfonamide (XIV) With Malononitrile, Acetyl Acetone Or Ethyl Acetoacetate In Absolute Ethanol Afford Triazole S XV, XVII And XVIII, Respectively.
The Reaction Of Triazole Compound XV With A Mixture Of Malononitrile And Sodium Ethoxide Produced Triazolopyridine XVI. Additionally, Hydrazinolysis Of Ester XVIII With Hydrazine Hydrate Gave Hydrazide XIX That Was Condensed With 4-Fluorobenzaldehyde In Absolute Ethanol Affording Compound XX.
Also, Triazole Ketone XVII Was Condensed With Hydroxylamine Hydrochloride, 4-Chlorobenzaldehyde Or 4-Hydrazineylbenzenesulfonamide Hydrochloride (Ia) To Give Compounds XXI, XXII And XXIII, Respectively.
Finally, Discussion Of In Vitro And In Vivo Results Of All Compounds In Addition To Ulcerogenic Liability Of The Most Active Compounds, Docking Study Using MOE, Conculsion Of The Results.
The Fourth Chapter Consists Of Experimental Part Of This Work Which Contains The Detailed Procedures Applied For The Synthesis Of All Previous Compounds. Also, Physical Constant, Elemental And Spectral Analyses Of The Novel Synthesized Compounds Are Given In This Chapter.
Additionally, It Contains Detailed Steps For The Docking Study Of Final Compounds With COX-2 Isozyme (PDB; 3LN1) Using Molecular Operating Environment (MOE, 2008) To Visualize Their Binding Interaction. It Also Describes Both In Vitro COX-1 & COX-2 Inhibition And In Vivo Anti-Inflammatory Activity Of All Synthesized Compounds Compared With Celecoxib As A Standard Anti-Inflammatory Agent.
Finally, This Chapter Clarifies The Results Of The Ulcerogenic Liability And The Histopatholgical Studies Applied For The Most Active Pyrazoles (Vib, Vid, Vif, Ixg, Ixj & Ixi), Tetrazoles (Xiiib, Xiiif & Xiiih), Standard Reference Drugs: selective COX-2 Inhibitors Celecoxib; And Non-Selective Nsaids; Indomethacin. Results Showed That All The Tested Compounds Were Less Ulcerogenic Than Indomethacin And Comparable To Celecoxib.
The Fifth Chapter Includes 153 References from 1950 To 2018.