الفهرس 
OsteoporosisOnly 14 pages are availabe for public view
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Abstract
Osteoporosis is a multifactorial progressive skeletal disorder, characterized by reduced bone mass and deterioration of bone microarchitecture. This predisposes bones to an increased fracture risk. In Egypt osteoporosis is a very old disease, as it was already present in ancient Egyptians.
The present study was performed to compare the therapeutic effects of the use of some natural means to conventional drug therapy (alendronate) and prevention of drug adverse effects, on osteoporosis. This was evaluated through the determination of the serum levels of some biochemical markers and histopathological examination of bone samples, affecting bone remodeling on osteoporosed-induced rats by the administration of dexamethasone in female adult albino rats.
Results denoted that olive oil and lepidium sativum (in the tested doses) had a beneficial therapeutic role in treatment of osteoporosis as compared to alendronate or other drug therapy.
It was found that there was a significant increase in serum Ca2+, P3+ and osteocalcin levels in all the treated groups. Still it was highest in the group which received a combination of both olive oil and lepidium sativum concurrently.
Olive oil has beneficial effects on bone health, as it might increase the formation of osteoblasts from the bone marrow stem cells. Besides, it owes an anti-inflammatory, antioxidant and estrogenic activities.
Lepidium sativum has positive effect of on bone density, which might be due to its rich content of calcium. In addition, the high content of docosahexaenoic acid and eicosapentaenoic acid , all of which have beneficial effects on bones