الفهرس | Only 14 pages are availabe for public view |
Abstract Sixty male albino rats (150- 200 gm) were employed in the present work. Rats were purchased from the laboratory animal’s farm, Faculty of Veterinary Medicine, Zagazig University. The rats were accommodated for two weeks before being used. Rats were alienated into six groups compromising ten rats each (n=10). Groups were designed as: group I: Control C (received physiological saline 2ml/rat for 60 days) group II: Corn oil CO (received CO 2ml/rat for 60 days) group III: Camel milk CM (received CM 2 ml*/ rat for 60 days) group IV: FNP Treated (received FNP 7.09 mg/kg B.wt ”1/10 LD50” of FNP* for 60 days) group V: CM + FNP pro/co treated; received CM firstly for 15 days then received CM + FNP for 60 days by the same doses, route and duration) group VI: FNP + CM co treated (received FNP followed by CM 1 hours later for 60 days by the same doses, route and duration) The current study was conducted to elucidate the in vivo geno-toxic and immune-toxic impacts of the FNP pyrethroid in the male rats via estimation of hematological and immune related indices along with the impact of FNP on the expression pattern of cytochrome P450 (CYP1A1) in liver. Assessing DNA damage induced by FNP via comet assay in whole blood, liver, and spleen. Investigation the histo-pathological changes in liver, spleen and thymus gland of the exposed rats. Secondly; to explore the modulatory action of CM in amelioration of the FNP induced alterations. |