الفهرس 
INTRODUCTIONOnly 14 pages are availabe for public view
 |  | from | 151 |  |  |
| | | from | 151 | | |
Abstract
Diabetes mellitus (DM) is a group of metabolic disorders characterized by a chronic hyperglycemic condition resulting from defects in insulin secretion, insulin action or both. Permanent neonatal diabetes is caused by glucokinase deficiency, and is an inborn error of the glucose-insulin signaling pathway. The prevalence of diabetes is increasing rapidly worldwide. DM is also commonly associated with elevated oxidative damage. There is an appositive association between Zn deficit and DM. Its decreased content in the pancreas can decreased the capacity of islet beta-cells to synthesis and release insulin.
Therefore, this study was conducted to scrutinize the potential efficacy of ZnONPs in streptozotocin (STZ)-NA induced diabetes in rats based on measuring blood glucose and insulin levels, lipid profile and antioxidant scavenging capacity plus histopathological changes.
For this purpose, forty adult male albino rats were randomly allocated into four equal groups as follow:
group I, Control group, received 0.5ml distilled water orally once daily for 30 days.