الفهرس 
IntroductionOnly 14 pages are availabe for public view
 |  | from | 138 |  |  |
| | | from | 138 | | |
Abstract
CNO is a severe disabling complication of diabetes, presents as a red, warm, swollen foot or ankle in a patient with diabetic neuropathy. It is characterised by progressive osteolysis, that lead to multiple fractures and joint destruction which can results in severe deformity with ulceration, and eventually amputation. The prevalence of charcot foot in diabetes is not clearly known, it ranges from 0.08% to 7.5% in diabetic patients. It may be easily overlooked by the non-specialists, especially in early stages. The present study was carried out on 50 consecutive patients with CNO and 50 consecutive patients with diabetic neuropathy selected from the diabetic foot clinic and diabetic neuropathy clinic, Internal Medicine Specialized Hospital, Mansoura University, as well as 50 healthy control. All subjects were subjected to full history taking, and clinical examination. Study of Osteoprotegerin G1181C and T245G Polymorphisms were done in stem cell unit in Mansoura Faculty of Medicine and other laboratory investigations were conducted in the laboratories of the Mansoura Specialized Hospital. The results of this study could be summarized as follows: charcot disease was significantly increase in diabetics who were on insulin treatment, had history of foot trauma or surgery other than revascularization surgery, and also who had longer duration of diabetes when compared to group of DN without charcot. DM with charcot group was significantly associated with lower NSS, higher frequency of painless neuropathy and higher NDS when compared to DN without charcot group. DM with charcot group was significantly associated with lower hemoglobin, higher total TLC, ESR, positive CRP when compared to DM without charcot group. Presence of ulcer was significantly associated with chronic charcot. from this study we concluded that: Genetic factors, particularly the OPG gene polymorphisms, play an important role in development of diabetic charcot neuroarthropathy. There are inter-population differences in phenotypic effects of these polymorphisms on the risk of development of diabetic charcot neuroarthropathy ,the current study concluded protective role of C allele as regard rs2073618 gene in Egyptian population.