الفهرس 
Synthesis of thiazolidine-2,4-dionesOnly 14 pages are availabe for public view
 |  | from | 111 |  |  |
| | | from | 111 | | |
Abstract
Cancer is one of the leading causes of death in the world, particularly in developing countries. Though advances in cancer therapy and diagnosis have considerably improved life expectancy, the overall survival rate of patients still remains poor. Disseminated cancer at the time of diagnosis and acquisition of tumour resistance are two main reasons. The growing knowledge of the biochemical pathways involved in a disease process increases the possibility to develop new drugs and approaches to treat this disease. An extremely promising strategy for cancer treatment is the chemotherapy, which is defined as the use of synthetic or natural drugs (alone or combination) to block the development of cancer in humans. Two major obstacles for the successful use of chemotherapy in cancer treatment are tumor cell resistant and the need for tumor cell specificity to avoid toxicity to normal tissues. Therefore, new efficient and specific drugs in the treatment of cancer are urgently needed to surmount current issues such as low efficacy, significant side effects and tumor cell resistance. In light of the above-mentioned considerations, the objective of this study was to synthesize potential anticancer lead compounds based on thiazolidinedione and/or rhodanine scaffolds. Literature survey showed amongst all heterocyclic rings, 2,4-thiazolidinedione and rhodanine surrogates play an important role in many dysfunctions of body like diabetes, , viral diseases and cancer. Furthermore, hybridization of two or more bioactive molecules often leads to increase activity due to synergistic effects (Figure1). To examine this proposal, modifications were made at the thiazolidinedione skeleton to allow the installation of rhodanine pharmacophore as one of the 4-thiazolidinones subtype. Our objective was to synthesize thiazolidinedione- rhodanine hybrids with the aim to fulfill the structure activity relationships as well as to establish how this modification affects anticancer activity.