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العنوان
Coordination Chemistry of Pyrazolopyridine and Its Azo Compound with Some Transition Metal Salts /
المؤلف
Abdel-Hamed, Eman Hamdy .
هيئة الاعداد
باحث / ايمان حمدي عبد الحميد سعد
مشرف / ممدوح سعد مسعود
مشرف / سعيدة ابو الثنا ابو العينين
مناقش / حسن على الدسوقى
مناقش / ممدوح سعد مسعود
الموضوع
Saeyda A. AbouEl-Enein Preparation of Azo Ligand . Antitumor Activity.
تاريخ النشر
2019
عدد الصفحات
104 P.:
اللغة
الإنجليزية
الدرجة
ماجستير
التخصص
الكيمياء
تاريخ الإجازة
7/1/2020
مكان الإجازة
جامعة المنوفية - كلية العلوم - الكيمياء
الفهرس
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Abstract

The present thesis comprises three main chapters in addition to Arabic and English summaries as well as relevant references. The data in this thesis are collected in (17 Tables), (36 Figures), (15 Schemes). And list of references is given and containing 151 references.
The First Chapter: Introduction
The chapter is concerned with a scientific literature survey related to pyrazolopyridine, uracil, azo compounds and their metal complexes especially from their biological activity and structural viewpoints.
The Second Chapter: Experimental
This part describes the preparation of ligands; 4,6-dimethyl-1H-pyrazolo[3,4-b]pyridine-3-amine and 5-((4,6-dimethyl -1H-pyrazolo [3,4-b] pyridin-3-yl) diazenyl) pyrimidine -2,4 (1H,3H)-dione, and their metal complexes (Mn(II), Pd(II), Fe(III), Cr(III), Ru(III), Zr(IV), Hf(IV) and UO2(II) ) and (Cu(II), Co(II), Ni(II), Cr(III) and Ru(III)), respectively. Different instrumental methods are used to investigate the structure of all these systems as elemental analyses, spectral techniques (IR, UV–Vis, 1H NMR and mass spectra for the ligands), magnetic susceptibility, molar conductance of complexes and thermogravimetric studies. Finally, the biological activity (antitumor and antimicrobial) of the prepared ligands and some of their metal complexes are evaluated.
The Third Chapter: Results and Discussion
This chapter is divided into two parts:
Part I
An extraordinary range of properties for HL1 ligand are exhibited by the prepared complexes. The analytical and spectral data depict that:
1- The 1:2 (M:L) molar ratio reaction of chloride salts (Mn(II), Pd(II), Fe(III), Cr(III), Ru(III), Hf(IV) and Zr(IV)) and UO2(II) nitrate with the (HL1) ligand produced complexes with 1:2 and 1:3 (M:L) molar ratios.
2- All complexes are non-electrolyte and they have octahedral structure, except Pd(