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Abstract One of the frequent musculoskeletal problems is knee pain. The trend of increasing of knee pain among the populations is noted. Therefore, choosing a reliable screening tool with reasonable cost is mandatory. Although MRI is the gold standard imaging modality for knee soft tissue structures, it has been widely abused with its high cost. US is an established modality to image the soft tissuestructures of the knee. Our aim isto detect the reliability of US in diagnosing cases with knee pain as compared to MRI. Our study included twenty patients with knee pain. Every patient underwent MRI and US examinations independentely and blindly. US is tested in detecting soft tissue structures pathology such as knee effusion, meniscal pathology (tear, degeneration and extrusion), medial collateral ligament, lateral collateral ligament and bursitis (Baker’s cyst) apart from the cruciate ligaments. It revealed that US showed an overall sensitivity of 61.7% and specificity of 92.7% with accuracy of 86.9%. The overall PPV and NPV were 66.1% and 91.3% respectively. So we can conclude that: Ultrasound is an effective imaging modality that can be suitable as a screeningtool for patients having knee pain. Knee US has reasonable accuracy in detecting collateral ligament and meniscal pathology. US with the advantages of being widely available, lower in cost and with no contraindications should bethefirst modality of choice in evaluating knee pain. MRI can be reserved forequivocal US results. Knee pain: US and MRI correlation Page | 85 References Abdrabou A. Patellar tendinitis (Jumper’s knee). Radiopaedia. (2013). Alves T. I., Girish G., Brigido M. K., et al. US of the knee: Scanning Techniques, Pitfalls, and Pathologic conditions. Radiological Society of North America.Volume:36 (6), Page 1759-1775 (2016). Beggs I., Bianchi S., Bueno A. et al. 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