الفهرس 
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Abstract
Gentamicin is an effective, widely used aminoglycoside antibiotic,active against severe and life-threatening infections however ,the risk of nephrotoxicity and oxidative damage limit its clinicaluse. Hence, the subject of our work was to explore the alleged ameliorative effect of both thymol and carvacrol on gentamicin-induced side effects mainly nephro and hepatotoxicity.
Thirty adult male albino rats of 150-200g average body weightwere allocated into five equal groups each containssix rats
The total test period was 12 days and experimented groups were demonstrated as follow:
group 1 : (C) (Control) Rats in this group received normal saline orally
group 2 : (Tw) (Tween) Rats in this group received tween 80 orally.
group 3: (G) (Gentamycin treated group) Rats in this group IP received Gentamycin at dose of 100 mg/kg B.Wt once daily for 12 successive days.
group 4: (TG) (Thymol + Gentamicin treated group) Rats in this group I/P received gentamicin at dose of 100 mg/kg B.Wt once daily and orally received thymol at dose of 20 mg/kg B.Wt once daily for 12 successive days.
group 5: (CG) (carvacrol + Gentamicin treated group) Rats in this group I/P received gentamicin at 100 mg/kg B.Wt once daily and orally received carvacrol at dose of 15 mg/kg B.Wt once daily for 12 successive days.
At the end of experimental period(12 days) , blood samples were collected in tubes containing anticoagulant for measurement of haematological parameters and tubes without anticoagulant for examination of serum biochemical parameters; liver and kidey function parameters, and serum inflammation markers. Liver and kidney were taken for studying tissue anti-oxidant enzymes activities and evaluation of histopathology.