الفهرس | Only 14 pages are availabe for public view |
Abstract Replacing invasive with noninvasive monitoring could be possible with developments in technology this would help increase safety during live liver donation. Primary goal is to investigate Primary goal is to investigate Plethysmography Variability Index (PVI) (%) and Stroke Volume Variation (SVV) (%) of Electric Bioimpedance Cardiometry (EC) intraoperative ability to monitor changes and to study their inter-relationship and agreement with each other and with the Central Venous Pressure (CVP) (mmHg) during right hepatotomy for live liver donation This is a Clinical Trial and Diagnostic Test Accuracy study with Local Ethics Committee of Faculty of Medicine, Menoufia University at 28 May 2018 and National Liver Institute research board approval (NLIIRB 00152/2018. The study was conducted at the Anaesthesia Department of the National Liver Institute, Menoufia University between June 2018 and December 2018. This trial was also registered at the Pan African Clinical Trial registery (PACTR201902855547795). PVI (%) (Masimo, Irvine, USA) and SVV (%) (EC, Osypka Germany), mean Invasive arterial blood pressure (IBP) (mmHg) and CVP (mmHg) were recorded: 10 min after induction. (T0), Dissection phase: 1 h after opening fascia and 2 hourly (T1-3), post-resection. (T4), end surgery before muscle relaxant reversal. (T5). Guided anaesthesia depth and a PEEP 5 cmH2O applied. Crystalloids infused 0 - 6 ml/kg/h during dissection and 0 - 10 ml/kg/h post-resection, Additional colloid boluses post-hepatotomy to increase and maintain CVP (6-12 mmHg). The UOP (>0.5 ml/kg/h) and mean IBP (>60 mmHg) were maintained throughout surgery with colloids and / or norepinephrine. Blood if Haemoglobin >8g/dl Results are presented as Median [IQ]. 34 donors, age 26.0 [21.0-34.0] y, 64.7% Males, Weight 72.0 [70.0-80.0] kg, Body Mass Index 25.9 [24.0-27.1 kg/m2, Anaesthesia time 7.5 [7.0-8.0] h, Blood Loss 400.0 [400.0-500.0] ml, Ringers Acetate 4000.0 [3500.0-4500.0] ml, Colloids 250.0 [0-500.0] ml, UOP 1.4 [1.30-1.7] ml/kg/h. No blood products. |