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Abstract Axonal loss is usually quantified with OCT based on peripapillary RNFL thickness measurements; however, measurements of RNFL thickness can also be used to estimate the amount of retinal ganglion cell loss. The purpose of this study was to evaluate the retinal nerve fiber layer thickness changes and ganglion cell count measured by optical coherence tomography in idiopathic intracranial hypertension (IIH). The study involved 50 patients with pseudotumor cerebri represent group (I) and 50 age and sex matched normal persons represent the control group (II). Optical coherence tomography is used to measure the RNFL & GCL thickness to determine if their thickness affected by the disease idiopathic intracranial hypertension (pseudotumor cerebrai). Comparison between both groups shows a statistically highly significant difference (P < 0.01) as regard visual acuity (VA). The intracranial tension showed a statistically non-significant difference between both groups. Comparison between both groups shows a statistically non-significant difference (P > 0.05) as regard spherical error and there is a statistically significant difference as regard cylindrical error (P <0.05). There is a statistically significant difference comparing intracranial tension in both study groups (P <0.05). The study shows that there was an increase in the RNFL thickness in the IIH group compared to control. There is a statistically very highly significant difference between both groups (P <0.001). |