Search In this Thesis
   Search In this Thesis  
العنوان
Serum Ischemia-Modified Albumin in Children with Epileptic Seizures /
المؤلف
Saad, Amr Mohamed Fathi El-Faramawy.
هيئة الاعداد
باحث / عمرو محمد فتحي الفرماوي سعد
مشرف / أحمد ثابث محمود
مناقش / مها عبد الرافع البسيىوني
مناقش / نهلة محمد سعيد عبد الهادي
الموضوع
Serum albumin.
تاريخ النشر
2019.
عدد الصفحات
120 P. :
اللغة
الإنجليزية
الدرجة
ماجستير
التخصص
طب الأطفال ، الفترة المحيطة بالولادة وصحة الطفل
تاريخ الإجازة
15/12/2019
مكان الإجازة
جامعة المنوفية - كلية الطب - قسم طب الأطفال
الفهرس
Only 14 pages are availabe for public view

from 133

from 133

Abstract

Epilepsy recently adopted by the International League Against Epilepsy (ILAE) as a disease of the brain that is affected by any of the following conditions: (1) At least two unprovoked seizures occurring more than 24 hours apart. (2) One unprovoked seizure and a probability of further seizures occurring over the 10 years later. (3) Diagnosis of an epilepsy syndrome
Ischemia-modified albumin (IMA) is a metabolic variant of protein generated during acute ischemic conditions due to a decrease in binding capacity of albumin for transition metals; it is approximately 1% to 2% of the total albumin concentration and increases to 6% to 8% in patients experiencing ischemia. During acute ischemic conditions, the metal binding capacity of albumin for transition metals such as copper, nickel, and cobalt is altered, producing a metabolic variant of the protein, commonly known as IMA.
The aim of this study was to detecting the changes of IMA levels in epileptic seizures (ESs), its clinical importance and its relation with the seizure duration.
This case-control study was conducted on 80 children, 60 epileptic children: 20 epileptic children with seizure duration less than 5 minutes, 20 epileptic children with seizure duration from 5 to 15 minutes, 20 epileptic children with seizure duration more than 15 minutes. They were compared with 20 apparently healthy children of matched age and sex as a normal control group.
All children were subjected to: history and clinical examination, neuroimage (when needed), routine lab (CBC, ALT, AST, serum creatinine, Serum Albumin, serum electrolytes and RBS),