الفهرس | Only 14 pages are availabe for public view |
Abstract Ovulation induction is the use of medication to stimulate normal ovulation in women with ovarian dysfunction. Human Chorionic Gonadotrophin (HCG) in combination with clomiphene citrate (CC) has been used as an alternative to LH for many years and this procedure is considered as a standard method for inducing final stages of oocyte maturation. HCG is an expensive medicine which needs monitoring. Several studies have been conducted to clarify the role of oxytocin (OT) in central and peripheral tissues, such as uterus, placenta, amniotic sac, corpus luteum, testes and heart. Oxytocin hormone in addition to its contraction stimulating property acts as a regulator of GnRH and LH release. There is evidences that oxytocin has a role on regulation of GnRH secretion, release of LH and progesterone secretion. On the other hand, administration of oxytocin antagonist resulted in decreasing of LH concentration. Several studies have been conducted to clarify the role of oxytocin on ovulation induction. The role of OT in regulation, timing and initiation of ovulation still controversial. Several studies suggested that OT has a possible role in the process of ovulation. Oxytocin injection has a stimulatory effect on induction of ovulation. Oxytocin may be considered as a viable alternative to HCG for triggering ovulation in infertile patients. Oxytocin mimics physiological condition, increases LH androgen, induces final stages of oocyte maturation, facilitates follicular rupture and maintains corpus luteum. The aim of this study was to compares the effect of oxytocin versus HCG versus a combination of both as a triggering of follicular rupture. |