الفهرس | Only 14 pages are availabe for public view |
Abstract Intracoronary thrombus formation due to atherosclerotic plaque rupture and the interruption of coronary blood flow constitute the main pathophysiology underlying acute coronary syndrome .The quantity of theintracoronary thrombus burden is associated with a poor prognosis in patients with Acute coronary syndrome. ( Sianos G et al .,2007) , (Singh M, Berger PB et al ., 2001). Intracoronary thrombus management is still complex, although many pharmacological and invasive treatments have been developed, such as glycoproteinIIb/IIIa antagonists and thrombectomy. Identifying predictors of the intracoronary thrombus burden may contribute to the management of patients with acute coronary syndrome . Recently, the red cell distribution width (RDW) and bilirubin level were shown to predict the thrombus burden in patients with Acute coronary syndrome. (Tanboga IH et al ., 2014) , (Hamur H et al .,2016). Many studies have described the protective effects of serum HDL-C levels in the atherosclerotic process. Recently, MHR was reported to be a new cardiovascular prognostic marker in chronic kidney disease. The MHR is also associated with CAD severity and complexity in stable CAD. The aim of this study is assessment relationship between MHR (Monocyte HDLCholestrol Ratio) and thrombus burden in patients with Acute Coronary Syndrome. This prospective study included 138 patients with ACS who were admitted to CCU department in National Heart Institute Menoufia University Hospitals, Menoufia from JUNE 2018 to APRIL 2019 . The patients were grouped into 2 groups: group of low thrombus burden (grades 0-3) and group of high thrombus burden (grades 4 and 5). |