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Abstract Arterial calcification is common in patients with CKD and ESRD and may contribute to the excess cardiovascular mortality in this population.(Duhn et al., 2011) VC has been associated with mineral bone disease in CKD patients and the general population, stressing the fact that both disorders can share a pathway of pathogenesis.(Román-García et al., 2011) Many risk factors are involved in the pathogenesis of VC but the main is an imbalance between promoters and inhibitors of VC.(Hassan et al., 2012) Because BAC is a marker of generalized MAC, mammography was used to detect MAC in women with different CKD stages.(Abou-Hassan et al., 2015) This is a Case control study with target population includes 88 female participants and were divided over 4 groups with each group include 22 female as follow: cases include women with CKD stage 2, 3& 4 (group A, B, C) attended nephrology clinic and admitted in Internal medicine department in Suez Canal University Hospital and Control group includes women with normal kidney function (group D). Patients with documented CVD, DM, Acute renal failure, CKD stage 1 & 5, Age <18 years or > 60 years old, history of mastectomy and those who refused to participate were excluded from the study. The participants were subjected to history taking, mammography and taking blood samples for checking lipid (LDL, HDL, Triglycerides, cholesterol and VLDL) and metabolic ( Cr, Ca, P, Mg, PTH and Intact FGF23) profiles Our study was conducted aiming at early detection of medial VC in different stages of CKD (stage 2, 3, 4) patients and its frequency among these stages. The age ranged from 19 years to 60 years with a significant difference in age between all groups regarding hypertension, dyslipidemia, BAC, and lipid & metabolic profiles while no significant difference regarding use of anticoagulant. |