الفهرس 
Imidacloprid trade name Commando 30% insecticide
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Abstract
Pesticides are extensively used all over the world since the human realization to control the harmful effects of pests on different crops and food stuffs to cater maximum yield of growing human population. Neonicotinoids are widely used plant systemic insecticides developed in the last some decades. Imidacloprid is an extensively used for crop protection worldwide from the last decade due to its low soil persistence and high insecticidal activity at very low application rate. Imidacloprid exposure leads to block a type of neuronal pathway which causes the accumulation of acetylcholine which leads to paralysis and eventually death of the insect pests. In Egypt, Imidacloprid is registered under many trade names including Best (25% Wp), Chinook (35% Sc), Command (30% Sc), Confidante (35% Sc), Confidor (20% SC), to control aphids, thrips and whitefly on several crops including tomato plants. So, the present study aims to investigate the toxic effect of acute and long-term exposure (chronic) of the organphosphorus insecticide Imidacloprid (Command 30%) on biochemical, physiological and histological parameters of exposed mice. In the present study a total of 100 adult male Swiss albino mice CD- 1were used in the experiment animals were divided into five groups (Three replicas of each 20 mice). The first group was served as control group, and mice were i.p injected with 100 μl PBS daily for 6 weeks. The second group mice were i.p administrated with 200 mg/kg vitamin C daily for 6 weeks. The third group was i.p. treated with sub-lethal dose of Command 30% Summary and Conclusion 59 insecticide equivalent to 1/20 LD50 (10.5 mg/kg b.w.) daily for 6 weeks. The fourth group mice were i.p. inoculated with Vitamin C (200 mg/kg) and 60 minutes later they i.p. treated with (1/20 LD50) daily for 6 weeks. The fifth group was Command recovery for one week post last Command dose.