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العنوان
A Study to evaluate the effect of Dexmedetomidine infusion versus Magnesium sulphate infusion on Emergence Delirium in pediatric patients undergoing lower abdominal surgery /
المؤلف
Mahmoud, Esraa Alaa El-Dien.
هيئة الاعداد
باحث / Esraa Alaa El-Dien Mahmoud
مشرف / Hany Mohamed Mohamed El Zahaby
مشرف / Assem Adel Moharram Ahmed Moharram
مناقش / Anis Fikry Anis Asaad
تاريخ النشر
2019.
عدد الصفحات
118p. :
اللغة
الإنجليزية
الدرجة
ماجستير
التخصص
التخدير و علاج الألم
تاريخ الإجازة
1/1/2019
مكان الإجازة
جامعة عين شمس - كلية الطب - التخدير والرعاية
الفهرس
Only 14 pages are availabe for public view

from 118

from 118

Abstract

SUMMARY
E
mergence delirium (ED) is a clinical state during emergence from general anesthesia in which patients are awake but have an altered mental state.
Its underlying cause remains unknown. Age, preoperative anxiety, anesthetic technique or agents, surgical procedure and pain are all suggested to play a role in its development
Variety of medications such as analgesics, opioids, α2-agonists, benzodiazepines have been used to control this state
Dexmedetomidine is a highly selective α2-agonist with anxiolytic, sedative, and analgesic properties, that has been used to decrease postoperative analgesia and opioid consumption with its sedative effect and thus controlling Emergence delirium
Magnesium sulphate is a physiological calcium channel blocker and a non-competitive N-methyl D-Aspartate (NMDA) receptor antagonist with an anesthetic, antinociceptive and anticonvulsant effect that has been used intraoperative for its analgesic sparing effect and controlling postoperative pain associated agitation.
The study was conducted on 100 preschool aged children with a double blinded allocation and randomization in which 50 patients received dexmedetomidine loading dose (0.5 µg/kg over 10 min) and infusion dose (0.2 µg / kg / hr.)
And the other 50 patients received magnesium sulphate loading dose (30 mg/kg) over 10 min. and infusion dose
(10 mg/kg/hr).
The main result of this study is the significantly lower incidence of emergence delirium during the first 20 minutes postoperative with intraoperative administration of intravenous dexmedetomidine infusion preceded by a loading compared to magnesium sulphate infusion preceded by a loading dose in lowering the incidence of emergence delirium in preschool aged children undergoing lower abdominal surgeries