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Abstract Acute STEMI is the most severe form of IHD and it leads to significant morbidity and mortality, PPCI is the best reperfusion strategy in acute STEMI if done in appropriate time, hence PCI capable centers are not covering all the country and so transfer time of STEMI patients for PPCI takes long time and prolongs reperfusion time, so pharmaco-invasive strategy is as effective as PPCI specially in developing countries like in Egypt by giving thrombolytic therapy and transferring patient for coronary angiography. Revascularization guidelines focus on shortening reperfusion time in order to get better outcome in STEMI patients. This study aimed to investigate outcome of patients presenting with acute STEMI who were treated with PPCI with those treated with pharmaco-invasive strategy. 139 patients enrolled in this study, group (A) - 73 patient treated with PPCI, group (B) - 66 patient treated with pharmaco-invasive strategy, 9 patients (13.5 % of group B) needed early intervention (rescue PCI). The results were statistically analyzed, and it was found that: There was significant statistical difference between both groups as regards primary angiographic endpoints, but there was no significant statistical difference between both groups as regards composite secondary endpoints of death, reinfarction or disabling stroke, cardiogenic shock was more significant in group A. |