الفهرس 
Aim of the WorkOnly 14 pages are availabe for public view
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Abstract
Background: Prostate cancer is the most frequently diagnosed solid malignant tumor among men. The morbidity and mortality directly attributable to this common malignancy are considerable. However, in a non negligible proportion of patients, the disease may be considered relatively indolent.
Aim of the Study: To illustrate the usefulness of quantitative diffusion weighted MRI with measured ADC values in predicting the aggressiveness of prostate cancer.
Patients and Methods: During a period of 6 months duration from January 2019 to June 2019, 25 patients were enrolled in the study. All patients with elevated PSA values greater than 4 ng/mL underwent sextant TRUS guided biopsies. MRI examination was done either prior to the TRUS biopsy or at least 3 weeks after the TRUS biopsy.
Results: The 25 patients enrolled in this study were ranging from 59 to 85 years with mean age of 71 years. The total PSA was elevated ranging from 10.9 to 905.5 in all patients. Regarding the
histopathological type of the diagnosed prostate cancer patients, all had adenocarcinoma.90% of the lesions are located in the peripheral zone, 10% are located in the central zone and 5% are located in the
transitional zone. (5% of the lesions are located in both the peripheral and central zones) .90% of the lesions are localized by the T2 WI. In about 10% the lesions is not well identified by the T2 WI. We found that the mean ADC decreases as the Gleason score increase which helps as to discriminate between low grade, intermediate grade and high grade prostate cancer with a significant p value < 0.001 .
Conclusion: ADC values showed a negative correlation with GS. This study suggests that ADC values may allow the noninvasive assessment of biological aggressiveness of prostate cancer, which may contribute in planning initial treatment strategies.