الفهرس 
Aim and Plan of the workOnly 14 pages are availabe for public view
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Abstract
The PhD thesis includes aim of the work and three main chapters
I- Aim and plan of the work
The work aimed to prepare and characterize some new Schiff
bases and their metal complexes hoping to explore some
effective compounds to be used in treatment of some
microbial diseases.
II- Introduction
This chapter includes an overview of previous researches for
complexes of Schiff base ligands and their complexes and
also their applications.
III- Experimental
This chapter contains the chemicals and instruments used in
Practical part of thesis as follow:
1) Preparation of ligands and their metal complexes.
2) characterization of the ligands (1),(2) and their complexes using:
•Physical techniques such as molar conductances and magnetic
susceptibility
•Elemental analyses (C, H, N, Cl and M).
English summary
ii
•Spectral analyses as IR, UV- Vis., 1HNMR, mass spectra and
ESR measurements.
•Thermal techniques as DTA. and TGA
3) Measurement of antimicrobial activity
iv. Results and discussion
This chapter includes characterization of the ligands and their complexes.
The ligand (1) was prepared as follow:
1- Condensation of refluxing and stirring two hours of sodium salt of
p-hydroxy methyl benzote in presence of ethanol with
equivalent molar ratio of chloro ethyl acetate and few drops of
sulfuric acid was added to give the product (1).
2- To the product (1) formed, o-phenylene diamine in (1:2) molar
ratio was added in 50 cm3 ethanol and refluxed the mixture for
another 3hrs to give the product (2).
3- To the product (2) formed, add salicylaldhyde in (1:2) molar ratio.
The final solid product left to cool at room temperature, filtered
off, washed with water, dried and recrystallized from ethanol to
afford Schiff-base ligand [H2La] (1).
The ligand (2) was prepared as follow:
1- Condensation of refluxing and stirring two hours of sodium salt of
p-hydroxy methyl benzote in presence of ethanol with
equivalent molar ratio of chloro ethyl acetate and few drops of
sulfuric acid was added to give the product (1).
English summary
iii
2- To the product (1) formed, hydrazine hydrate in (1:2) molar ratio
was added in 50 cm3 ethanol and refluxed the mixture for
another 3hrs to give the product (2).
3- To the product (2) formed, add salicylaldhyde in (1:2) molar ratio.
The final solid product left to cool at room temperature, filtered
off, washed with water, dried and recrystallized from ethanol to
afford Schiff-base ligand [H2Lb] (2).
The reaction of the ligands (1) and (2) with Cu(II), Ni(II), Zn(II), Mn (II)
and Mg(II) complexes have been synthesized and characterized by (1HNMR,
mass, IR, UV-VIS, ESR) spectroscopy, (magnetic moments,
conductance) measurements, (elemental and thermal) analyses. The IR
spectral data show that, the Schiff base behaves as a neutral tetra dentate
ligand bonded to the metal ions through the azomethine nitrogen atom
and nitrogen atom in amine group which protonated or deprotonated form
adopting either octahedral or pentahedral geometries. Molar conductance
in DMF solution indicates that, the complexes are non-electrolytes. The
ESR spectra of solid show an axial type indicating a d(X
2
-y
2
) or d(Z
2
)
ground state with a significant covalent bond character. However, In
vitro biological screening tests of the ligands and their metal complexes
(1), (2), (3), (7), (13), (15), (18), (19), (20) and (22) carried out as
antibacterial and antifungal activity and presented in (figure 3). The
antibacterial activity was tested against two bacterial strains; Grampositive
Staphylococcus aureus and Bacillis subtilis as well as Gramnegative
Escherichia coli and Proteus vulgaris strains. The results
compared with standard drug (Ampicllin (Gram positive) and Gentamicin
(Gram negative). The data indicated that, complexes were active against
bacteria.