الفهرس 
IntroductionOnly 14 pages are availabe for public view
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Abstract
One of the most common causes of diabetic ulcer is a growth factor abnormality. Platelets are a rich source of growth factors. PRP improves wound healing. It acts as barrier that prevents bacterial invasion into the wound and promotes wound healing by releasing growth factors. PDGF is one of the growth factors that used alone to aid healing by attracting undifferentiated cells in the newly formed matrix and triggering cell division. PRP may suppress cytokine release and limit inflammation, interacting with macrophages to improve tissue healing and regeneration, but the application of PRP gives a better results.
Our study was conducted to evaluate the effectiveness of PRP injection in healing of diabetic ischemic wound after revascularization . This is a longitudinal study during which ( 30 ) patients were enrolled. The median age was 59.63 ±7.08, range 23. The gender distribution was 12 (40%) female and 18 (60%) male .A number of 24 (80%) of the patient participants underwent endovascular revascularization while only 6 (20%) Patients underwent open revascularization .
The participants were randomly divided into two groups. A number of 15 patients used PRP as a mode of dressing and the other 15 patients used the traditional methods. There is no significant association between the both groups regarding the post-operative complication (p value; 0.698) . there is significant strong inverted correlation between rate of healing and size of ulcers.
And there is significant strong proportional correlation between size of ulcers and treatment time (p=0.002) and there is significant strong proportional correlation between size of ulcers and the number of injections ( p=0.040).
However, the cost of the PRP technique were much higher than the traditional technique and p value was statistically significant (0.000).