الفهرس 
BronchiectasisOnly 14 pages are availabe for public view
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Abstract
Bronchiectasis (BE) is a complex chronic respiratory condition characterized by a “vicious cycle” of infection and dysregulated airway inflammation resulting in progressive decline in lung function associated with significant morbidity in children that extend beyond the respiratory system and include cardiac and psychological effects.
Chronic neutrophil-dominant airway inflammation is a key feature of bronchiectasis and activated neutrophils represent a key component of the “vicious cycle” of lung damage through the release of their harmful cellular contents, particularly, cell-derived proteases and reactive oxygen species.
In addition, airway secretions in patients with BE is rich in potent neutrophilic chemoattractant cytokines, including IL-1b, tumor necrosis factor-a, IL-8, and leukotriene B4 produced by the stimulatory effects of hyperactive alveolar macrophages. This persistent cytokine milieu results in chronic neutrophilic recruitment to the alveoli and progressive tissue damage.
In this cross sectional study was conducted on 30 children diagnosed as bronchiectasis following up in Pediatric Chest Clinic, Children’s Hospital , Ain Shams University and underwent flexible bronchoscopy and bronchoalveolar lavage during the period of September 2016 to December 2018.
The aim of this study was to evaluate the degree of bronchial inflammation in patients with bronchiectasis by measuring the levels of airway interleukin-8 as an inflammatory biomarker and assessment of bronchoalveolar lavage fluid neutrophilic count to correlate their values with disease severity.
IL8 levels were measured in BALF with a mean value of 237 ng/L. We found a significant correlation between IL8 levels in BALF and hospitalization last year. Also, higher IL8 levels in BALF were detected in patients with more severe radiological findings in HRCT and in those colonized with pseudomonas (Pa).
A statistically significant correlation was found between IL8 levels in BALF and values of FEV1 in spirometry and a significant correlation with neutrophilic count in BALF indicating that airways levels of IL8 levels correlate well with the of bronchiectasis as regard the symptom score, spirometry findings ,HRCT severity score.