الفهرس 
Persistent DiarrheaOnly 14 pages are availabe for public view
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Abstract
SUMMARY
Persistent diarrhea (PD) is still a major cause of morbidity and
mortality in the developing world and usually follows acute infectious
diarrhea. PD is commonly seen in association with significant malnutrition,
and the relationship between persistent diarrhea and malnutrition is
bidirectional. PD should be differentiated with other chronic diarrheal
diseases.
Progression from acute to persistent diarrhea is due to an interaction
between several complex pathophysiological mechanisms. Small bowel
injury has been incriminated as the central mechanism in PD. In PD, chronic
inflammation and defective intestinal repair result in abnormal mucosal
morphology, leading to poor absorption of luminal nutrients and increased
permeability of the bowel to abnormal dietary or microbial antigens. The
severity of these changes is greater in younger children due to delayed
intestinal mucosal maturation. Micronutrient deficiencies contribute to poor
intestinal repair and immunological responses that may result in prolongation
of mucosal injury and delayed intestinal repair mechanisms.
The influence of hyperbaric oxygen on bodily organs and tissues is
multidirectional. In the conditions of high partial concentrations, oxygen
becomes a drug inducing numerous significant phenomena in the body of a
sick child, the most important of which is the effect on cellular metabolism.
The use of hyperbaric oxygen is known to: increase the antimicrobial activity
of leukocytes; reduces the adhesion of neutrophils to the vascular walls
thereby limiting endothelial damage. It also leads to vasocontriction in areas
with a regular oxygen concentration without causing changes in circulation in
the areas with an impaired flow; restores fibroblast growth and collagen
production and ATP storage which reduces tissue oedema; limits some