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Abstract The present study was design to investigate the adverse effects of dexibuprofen and protective effect of Vit. E and to show the result of combination between dexibuprofen and Vit. E on hepatic and renal functions. Experimental design: After one week of administration 80 albino rats randomly allocated into 4 equal groups, each of 20 rats. The 1st group: Rats in this group were not medicated and left as control and received saline (0.9%) NCl as a vehicle. The 2nd group: Rats in this group given repeated oral doses of dexibuprofen (7.2 mg/kg b.wt) once daily for successive 21 days. The 3rd group: Rats in this group given repeated oral doses of Vit. E (18 mg/kg b.wt) once daily for successive 21 days. The 4th group: Rats in this group received a combination of Vit. E (18 mg/kg b.wt) once daily with dexibuprofen (7.2 mg/kg b.wt) once daily for successive 21 days. |