الفهرس 
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Abstract
Summary
This present study aimed to evaluate quality of life in patients with chronic progressing rheumatic diseases as patients with osteoarthritis and rheumatoid arthritis, and compare the quality of life in osteoarthritis and rheumatoid arthritis patients with disease activity, X-ray changes and laboratory investigations.
It was a case-control study conducted on 160 individuals divided into four groups; group (1); fifty (50) patients with OA of the knee diagnosed according to American college of Rheumatology (ACR) Revised Criteria for Early Diagnosis of Knee Osteoarthritis (Abari, 2016); and distributed as 26 male (52%) and 24 females (48%) with a mean age of (52.82 ±7.3) years old.
group (2); fifty (50) patients with RA diagnosed according to the American college of Rheumatology/ The European League Against Rheumatism (ACR/EULAR) Classification Criteria for Rheumatoid Arthritis (Singh et al., 2016); and distributed as 22 males (44%) and 28 females (56%) with a mean age of (53.88 ±8.1) years old.
group (3); thirty (30) healthy volunteers with no clinical features of OA matched in age and sex with the OA patients and distributed as 12 males (40%) and 18 females (60%) with a mean age of (50.93 ±6.5) years old, and with no statistically significant differences regarding age and sex with OA patients; matched in age and sex with the OA patients as control group for OA patients.
group (4); thirty (30) healthy volunteers with no clinical features of RA matched in age and sex with the RA patients and distributed as 9 males (30%) and 21 females (70%) with a mean age of (52.30 ±7.4) years old, and with no statistically significant differences regarding age and sex with RA patients, as control group for RA patients.
The Studied Patients were selected randomly as Rheumatoid arthritis and osteoarthritis patients without exclusion criteria over a period of one year from Rheumatology & Rehabilitation Department at Beni-Suef University Hospital. All the 160 individuals included in the study was subjected to a written informed consent for participation in the study, detailed history taking, clinical assessment and Rheumatologic examination. Disease activity was assessed in rheumatoid arthritis patients and osteoarthritis patients by DAS 28 and WOMAC score respectively. Assessment of quality of life was conducted using two scales (Short Form 36 (SF-36) and Health Assessment Questionnaire-Disability Index (HAQ-DI). Assessment of pain was done using Visual Analog Scale (VAS).
The results of the present study showed that the four groups had a similar age and gender distribution, the age of the four groups was ranged from 40-65 years with a mean age around (52.30 ±7.4) years with no significant difference between the four groups regarding their ages.
Short Form Survey (SF-36) score showed no statistically significant difference among OA patients as compared with RA patients (p-value of 0.751), SF-36 score was significantly lower among OA patients as compared with their healthy control volunteers and among RA patients as compared with their healthy control volunteers (p-values=0.001). The Health assessment questionnaire disability index (HAQ-DI) score was significantly higher among OA patients as compared with RA patients; (HAQ-DI) score was significantly higher among OA patients as compared with their healthy control volunteers and among RA patients as compared with their healthy control volunteers (p-values=0.001). VAS scale showed moderate positive correlation with HAQ-DI among studied RA patients. VAS scale showed moderate negative correlation with SF-36 among studied RA patients. Our findings showed no significant association between quality of life and patient’s age or disease duration.
The results of this study indicated the need for further research that would include a larger number of respondents homogenized by age, gender, comorbidities, socio-demographic parameters, duration of disease, etc. Assessing the impact of different interventions on the QOL should also be an important task that can help define a holistic and integrative model of treatment for rheumatic diseases.