الفهرس 
INTRODUCTION.Only 14 pages are availabe for public view
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Abstract
Lung cancer is the deadliest solid tumor, leading to. which deaths of more individuals than the combination of the three next most lethal cancers are colon, prostate and breast cancer.
According to the recent researches, in 2012 lung cancer accounted 13% (1.83 million) of cancer cases and caused 19% (1.56 million) of cancer deaths id wde.
Despite advances in surgery and drug discovery, lung cancer remains difficult to treat.
This is a result of unavoidable 1 exposure to carcinogens, poor diagnosis and the lack of targeted drug delivery platforms.
I Nanoparticles derived from natural proteins are biodegradable, metabolizable, and are easily amenable to surface modifications to allow attachment of drugs and targeting ligands.
< They have I been successfully synthesized from various proteins including water-soluble proteins (e.g., bovine and human serum albumin) and insoluble proteins (e.g., zein and gliadin). Proteins represent good raw materials since they have the advantages of synthetic polymers together with the advantages of absorbability and low toxicity of the degradation end products.
They hold certain advantages such as greater stability during storage and in vivo, being non-toxic and non-antigenic and their ease to scale up during manufacture over other drug delivery systems.
Albumin is an attractive macromolecular carrier that has been shown to be biodegradable, nontoxic, metabolized in vivo to produce innocuous degradation products, non-immunogenic, easy to purify and soluble in water allowing ease of delivery by injection and thus an ideal candidate for nanonarticle preparation