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Abstract Acrylamide (AA) is a low molecular weight, water soluble vinyl monomer it is odorless, colorless, rapidly polymerizable and crystalline substance. Acrylamide is found in carbohydrates-rich food prepared at high temperatures such as potato chips and French fries which are consumed by human. Its metabolite a glycidamide; an epoxide derivative; is more reactive toward proteins and DNA than acrylamide, the parent compound. Cytochrome P450 is known to be involved in AA metabolism in the liver changing it to glycidamide ,the active genotoxic product of AA .Fourty white male rats were randomly divided into 4 groups (10/group). GI: control group kept on balanced diet and tap water, GII: Acrylamide group received acrylamide orally in drinking water (7.5 mg/kg b.w.) for 30 days .GIII: treated with Copper (I)- nicotinate complex (400 μg/kg b.w.) after acrylamide intoxication for 30 days and GIV: Copper (I)-nicotinate complex then . |