الفهرس 
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Abstract
Androgenic alopecia, the commonest non scarring alopecia, is an androgen induced disorder characterized by hair loss in genetically predisposed men and women. In AGA, androgens induce miniaturization in hair follicles, especially in the fronto- temporal area and vertex of scalp in men; over the crown in women, as these areas are more sensitive to the effects of androgens.
Androgenic alopecia is known to depend on the presence of the androgen DHT and on a genetic predisposition for this condition, but its pathophysiology has not been fully elucidated. Patients typically present with the progressive thinning and shortening of hair in affected areas. Men and women with AGA are found to be susceptible to cardiovascular diseases, metabolic syndrome, diabetes mellitus, hypertension and also have a definite negative impact on self-image and self-esteem in these patients.
Ischemia-modified albumin has been licensed by the US Food and drug administration (FDA) for the diagnosis of suspected myocardial ischemia. It is considered a very sensitive marker of myocardial ischemia. Although it has a high negative predictive value, IMA detection can confirm the early diagnosis of cardiac ischemia.
Mean platelet volume which is a determinant of platelet activation, has been reported as elevated marker in cardiovascular risk factors patients such as atherosclerosis, metabolic syndrome, diabetes mellitus (DM), hypertension, and dyslipidemia.
The aim of the present study was to determine serum levels of ischemia-modified albumin and mean platelet volume in patients with androgenic alopecia and to assess correlation between these markers and the severity of the disease.
This study included 50 patients suffering from androgenic alopecia (25males and 25females), all patients were selected from the Outpatient Clinic of Dermatology and Andrology Department of Benha University Hospitals, in addition, 25 apparently healthy, age matched individuals as control group. Laboratory investigations were done to detect serum levels of ischemia modified albumin.
Results of the present study showed that:
1.Carotid intima thickness and serum levels of Ischemia modified Albumin (IMA) were significantly higher in cases as compared to controls .
2.Statistically significant correlations were found between serum levels of IMA marker and age, BMI, CIMT and duration of the disease.
3.There was no statistically significant difference in serum cholesterol, serum triglyceride and low density lipoprotein cholesterol and mean platelets volume (MPV) between cases and controls.
To conclude
from our study we conclude that Ischemia modified albumin has positive correlation with androgenic alopecia and can be used as a diagnostic and prognostic marker for atherosclerosis in male patients with AGA, while mean platelet volume has no relation with AGA and can’t be used in diagnosis or prognosis of atherosclerosis in AGA patients.