الفهرس 
Anatomy of the retina and optic nerve :
Multiple sclerosisOnly 14 pages are availabe for public view
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Abstract
Summary
Multiple sclerosis (MS) is a chronic autoimmune, inflammatory
neurological disease of the central nervous system (CNS) . Some
recent models support the presence of two connected mechanisms,
inflammation and neurodegeneration . Lesions of MS typically
develop at different times and in different CNS locations (i.e., MS is
said to be disseminated in time and space) .MS attacks the myelinated
axons in the CNS, destroying the myelin and the axons to varying
degrees.
The retina is a good model for the study of neurodegeneration
since it lacks myelin, meaning that changes in the GCL and RNFL
thickness will be due only to axonal damage .
The aim of this study to correlate between structural changes in
retina- imaged by OCT ( GCL and RNFL ) and optic nerve function
recorded by VEP in MS patients.
The study was conducted on 30 eyes of patients with MS. 15 eyes
of MS ON patients and 15 eyes of MS NON patients . In control
group, 10 eyes of normal subjects in same age group .
We studied OCT findings of MS patients ( average GCL
thickness and average RNFL thickness ) , Visual evoked Potentials
parameters ( P 100 peak time and N75-P100 amplitude ) and visual
Field mean deviation VF MD .
We reported a statistical significant thinning of GCL and RNFL
in MS patient especially MS ON more than normal subjects