الفهرس 
AIM OF THE WORKOnly 14 pages are availabe for public view
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Abstract
The thesis is composed of four main chapters in addition to Arabic and English summaries as well as relevant references
The first chapter: - Introduction
In this chapter, a literature survey was carried out and included the following items:
a) General introduction about hydrazones.
b) Defintion, nomenclature and preparation of hydrazones.
c) Modes of bonding of hydrazones in metal complexes.
d) Importance of hydrazones and their metal complexes in the following fields of applications:-
1- Biological application: -Antitumor, anti-mycobacterial and antimicrobial activity.
2- Pharmaceutical application: -Anti-inflammatory activity, hydrazones in treatment of iron overload diseases, antimalarial, anti-trypanosomal and anti- convulsant.
3- Catalytic applications:-In many fields such as some polymerization processes and some chemichal reactions.
4- Analytical applications:-Such as separation and determination of traces of metals and determination of some species in pharmaceutical formulations.
The second chapter:- Review of Literature
This chapter included a literature survey was carried out on hydrazones and their corresponding metal complexes.
The third chapter: - Experimental
In this chapter, the methods used for the preparation of two new hydrazone ligands and their copper(II), nickel(II), cobalt(II), iron(III), zinc(II), cadmium(II), lead(II), mercury(II), strontium(II), tin(II), thallium(I), silver(I), zerconyl(II), manganese(II), and uranium(II) complexes were described. The techniques used for characterization of different and their complexes namely are elemental, thermal analyses, infrared spectra, nucleolar magnetic resonance (1H-13CNMR), mass spectra, electronic absorption spectra, electron spin resonance, magnetic moment and molar conductivity measurements were also described.
The fourth chapter - Results and discussion:
This chapter divided into two main parts
Part 1. Synthesis, spectroscopic characterization and biological activities of transition metal complexes of (2-hydroxybenzylidene)hydrazono) ethyl)phenyl) ethylidene)hydrazono)ethyl)-2,4-dihydroxyphenyl)ethan-1-one) (H5L1).
Part 2. Synthesis, spectroscopic characterization and biological activities of transition metal complexes of 2-hydroxybenzylidene)hydrazono)ethyl)phenyl) ethylidene) hydrazono)ethyl)-2,4-dihydroxyphenyl)ethan-1-one (H5L).
The analytical and spectral studies showed that the first ligand which is namely, (2-hydroxybenzylidene)hydrazono)ethyl)phenyl)ethylidene) hydrazono) ethyl)-2,4-dihydroxyphenyl)ethan-1-one) (H5L1), chelated to the metal ions via azomethine nitrogen, protonated/deprotonated hydroxyl group of a salicyl moiety, behaving as a neutral or monobasic bidentate fashion in all complexes forming mononuclear complexes giving the following formulae [M(H4L)(OCOCH3)(H2O)2].nH2O (complexes (2), (7), (8) and (13)), [Zn(H5L)(OCOCH3)2] (10) and [M(H4L)(Cl)XY(H2O)].nH2O (complexes (14) and (18)). In addition to binuclear complexes giving the following formulae [M(H4L)2XY].nH2O (complexes (3), (9), (11), (12), (15), and (19)) and [M(H5L)2X2].nH2O (complexes (4), (5), (6), (16), and (17)). All the metal complexes were found to be non-electrolytic in nature possess octahedral or distorted octahedral geometry around the centre metal ions. All prepared compounds were screened against A. flavus, S. cerevisiae, B. subtilis and E. coli. The prepared compounds are more active against Fungi than bacteria. The promising active compounds against A. flavus, are complexes (1-6), (11-13), and (17-18) while complexes (2-6), (8), (11), (13) and (16-17) active against S. cerevisiae.
The second ligand which is namely, 1-(5-acetyl-2,4-dihydroxyphenyl) ethylidene)hydrazono)ethyl)-2,4-dihydroxyphenyl)ethylidene) hydrazono)-3-(hydroxyimino)pentan-2-one (H5L2) chelated to the metal ions via azomethine nitrogen and the nitrogen atom of the protonated /deprotonated oxime group, behaving as a neutral or monobasic bidentate fashion in all complexes forming mononuclear complexes giving the following formulae [Hg(H4L2)(OCOCH3)] (30), [Ag(H4L2)(OCOCH3)] (34) and [Zr(H4L2)Cl(H2O)] (35). In addition to binuclear complexe giving the following formulae [M(H5L2)2(OCOCH3)2] (complexes (21), (23) and (24)), [M(H4L2)2].nH2O (complexes (22), (25), (27), (28), (29), (31), (32), and (36)), [Fe(H4L2)Cl(H2O)] (26) and [Tl(H5L2)2] (33). All the metal complexes were found to be non-electrolytic in nature possess tetragonal distorted octahedral, tetrahedral or distorted octahedral geometry around the centre metal ions. All prepared compounds were screened against A. flavus, S. cerevisiae, B. subtilis and E. coli. The prepared compounds are more active against Fungi than bacteria. The promising active compounds against A. flavus, are complexes (20-22), (24-28), (30-33) and (36) while complexes (21), (22), (26) and (28) active against S. cerevisiae.