الفهرس 
Modification of the dissolution rate of poorly water soluble drugsOnly 14 pages are availabe for public view
 |  | from | 140 |  |  |
| | | from | 140 | | |
Abstract
Orally Disintegrating tablets (ODTs) are specially designed tablets that rapidly disintegrate in the mouth without chewing or even the need for water. The ODTs system, also known as Fast disintegrating tablets (FDTs), mouth melting tablets(MMTs) or mouth dissolving tablets.They have the unique property of disintegrating in the mouth in matter of seconds making them very useful in acute disease conditions. For chronic conditions, it is assumed to improve patient compliance to the medication due to the easy to use properties.These tablets fulfilled the medical needs for pediatric and geriatric patients who usually experience great difficulty in swallowing tablets. In addition to increased patients acceptability, these tablet offer many advantages compared to traditional tablets. An appreciable amount of the drug will be absorbed from oral mucosa bypassing the GI tract and hepatic portal systems. This is expected to increase the bioavailability of orally administered drugs which can otherwise undergo hepatic first-pass metabolism.
Recently the European Pharmacopoeia adopted the term orodispersible tablet as a tablet to be placed in the oral cavity where it disintegrates in less than 3 minutes before being swallowed. Commercially available ODTs are prepared by various techniques, mainly lyophilization , moulding and direct compression. The lyophilisation and molding techniques produce ODT that disintegrate within about 30 seconds, but suffer from low physical resistance and require specific packaging and handling conditions. On the other hand, tablets obtained by direct compression are less friable but disintegrate in a slightly longer time. Orodispersable tablets show many advantages over traditional one such as it bypasses the gastrointestinal tract and hepatic portal systems, increases the bioavailability of orally administered drugs which can otherwise undergo hepatic first-pass metabolism.However, this sequence requires rapid drug dissolution which is difficult to achieve with many valuable drugs. Optimizing drug dissolution rate is thus the limiting factor in formulation of these systems.Enhancing drug.